Archive for December 2009

Lung cancer after pneumonia diagnosis

In this large cohort of 40,744 patients hospitalized with pneumonia, 9% were diagnosed with a pulmonary cancer after a mean time of 297 days. Risk factors for subsequent cancer diagnosis included white race, prior cancer, and smoking. Close follow up after pneumonia in patients with these risk factors should be ensured (abstract)

If the problem is chaos, the solution is organization.

Rob Bessler writes... Happy holidays to all. While working the slow nights over the holidays, or while on the beach, I encourage you to take the time to get involved in the challenge of our times centered around meaningful improvements to healthcare delivery in the U.S. The best place to start is to get educated. One of the great challenges facing our nation is healthcare reform.  The enormity of our system, the complexity of all the different stake holders and the spiraling costs make the situation seem almost helpless. In the book, (more…)

Inappropriate antibiotics in sepsis

In this large retrospective multi-institutional analysis of 5715 patients with septic shock, initial receipt of appropriate antibiotics (based on subsequent cultures) had an odds ratio of survival to hospital discharge of 9.5 (CI 7.7-11.5). This study reinforces the need for obtaining adequate specimen cultures and starting broad spectrum antibiotics in patients with sepsis (abstract)

New IV drug for MRSA/VRE

Telavancin has been FDA approved for treatment of complicated skin/soft tissue infections due to multi-drug resistant gram positive organisms. It is an IV lipoglycopeptide with Qday dosing and no need for drug level monitoring. It was proven non-inferior to vancomycin in two phase 3 trials (abstract)