Antibiotic dosing difficulties with CVVHD

In this small prospective cohort of critically ill patients on antibiotics and CVVHD, researchers found wide variability in trough levels of various antibiotics, which did not appear to correlate with effluent flow rates; 15% were below minimum therapeutic levels, and 10% were excessive. Antibiotic dosing during CVVHD can be problematic, and should be supplemented by trough levels, when feasible, to avoid under and overdosing (abstract)

Danielle Scheurer

Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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