In this meta-analysis of 23 randomized CHF trials (>95% of patients had systolic dysfunction), pooled analysis showed beta blockers conferred a significant mortality benefit (risk ratio 0.76, CI 0.68-0.84). They did not find an association between mortality and beta blocker dose, but did find a linear association between mortality and heart rate (with an 18% relative risk reduction for every 5 fewer beats per minute). Beta blockers should be titrated by heart rate, not dose, to achieve mortality benefits in patients with systolic CHF (abstract).
Share This Post
Categories
Related Posts
While all of us see patients who smoke in their 70s or 80s, due to their limited lifespan from COPD, DM, malignancy, etc., and their expressed wishes to continue tobacco, we keep our admonitions to a minimum. We accept our patient has become learned enough through life to make their own decisions and accept whatever […]
Do you have a stack of journals piling up on your desk, beside your bed or in your email inbox? In 1950, medical knowledge was estimated to double every 50 years, but now the doubling time is every few months. At this rate, it is impossible to keep up with the literature, but a group […]
Fill in the Blanks: Q: “The diagnosis of type 2 MI is associated with a _____ prognosis. ___% of patients will live five years after their diagnosis.” The answer is a) POOR and b) a staggering 40%. I did not know that. However, what I am aware of is the ambiguity around Type 2 MIs and […]
Leave A Comment