In this large retrospective analysis of >82,000 Danish patients discharged after an episode of new atrial fibrillation, their risk of fatal or non-fatal bleeding was assessed according to post-hospital anti-thrombotics (ASA, clopidogrel, warfarin, or any combination). Using warfarin as the reference standard, risk of bleeding escalated with number of medications used, ranging from a hazard ratio of 0.93 for ASA monotherapy, to a hazard ratio of 3.7 for all 3 combined. The use of multiple anti-thrombotics significantly increases the risk of bleeding, so should be thoughtfully prescribed with that risk in mind (abstract)
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