Bleeding risk with multiple anti-thrombotics

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By  |  September 14, 2010 | 

In this large retrospective analysis of >82,000 Danish patients discharged after an episode of new atrial fibrillation, their risk of fatal or non-fatal bleeding was assessed according to post-hospital anti-thrombotics (ASA, clopidogrel, warfarin, or any combination). Using warfarin as the reference standard, risk of bleeding escalated with number of medications used, ranging from a hazard ratio of 0.93 for ASA monotherapy, to a hazard ratio of 3.7 for all 3 combined. The use of multiple anti-thrombotics significantly increases the risk of bleeding, so should be thoughtfully prescribed with that risk in mind (abstract)

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About the Author: Danielle Scheurer

Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.

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