BNP not useful in guiding CHF therapy

By  |  February 10, 2010 | 

In this single center trial of 364 adults with normal-EF CHF, they were randomized to 3 groups for 2 years: usual care, NT-proBNP-guided care, or intensive clinical assessment-guided care. 1 year mortality was less in the BNP and clinical management groups (9%) than the usual care group (19%). 3 year mortality was less in the BNP group (16%) than the other 2 groups (31%), but only patients <75 years old. BNP guided therapy does not alter short term mortality compared to intensive clinical management. More studies are needed to determine if BNP guided therapy is beneficial, and in what subgroups, but should not currently drive clinical management (abstract).

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About the Author:

Danielle Scheurer
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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