In this prospective registry of drug induced liver injury (DILI) patients in the US, the cause was antibiotics in 45% of cases (most common were amoxicillin, clavulanate, nitrofurantoin, isoniazid, and trimethoprim-sulfamethoxazole), CNS agents in 15%, and dietary supplements in 9%. At 6 months, 8% had died (less than half related to the liver injury) and 14% had persistent lab abnormalities (abstract).
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