The Association for Professionals in Infection Control (APIC) has released a comprehensive prevalence survey on the state of Cdiff in US healthcare facilities (from 648 facilities in 47 states) (link). They found 13 / 1000 inpatients were infected or colonized with Cdiff (94% infected). Over half (54%) were detected in <48 hours of admission (indicating infection at the time of admission), 20% had no history of antibiotic exposure (and 17% only exposed to surgical prophylactic antibiotics), and over half (53%) still had diarrhea after 6 days of treatment. This prevalence survey reminds us to be vigilant for Cdiff in all inpatients with diarrhea (with or without a history of antibiotic use), and to be patient with its treatment course (over half still with symptoms at 6 days).
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]