In this large industry-sponsored randomized non-inferiority trial, 2757 Japanese patients who had a (non-cardioembolic) cerebral infarction in the past 6 months were randomized to cilostazol 100mg BID or ASA 81mg a day. After a follow up of about 2 years, the primary endpoint (cerebral infarction, cerebral hemorrhage, or subarachnoid hemorrhage) occurred in significantly fewer cilostazol patients than ASA patients (2.8% vs 3.7%). Cilostazol patients also had fewer hemorrhagic events (0.8% vs 1.8%), but more side effects (headache, diarrhea, tachycardia). If proven effective in a more generalized patient population, and if tolerable from side effects, cilostazol may become an alternative agent to ASA for secondary stroke prevention (non-cardioembolic) (abstract).
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September 13, 2010 |
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About the Author: Danielle Scheurer
Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.
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