In this large randomized study of 3761 patients on clopidogrel and ASA, they were randomized to omeprazole or placebo. Rates of GI bleeding were significantly lower in the PPI group, and rates of CV events were also lower in the PPI group (although not significantly different). Although relatively short follow up (median about 3 months), this study adds further evidence that there is not a meaningfully significant interaction between clopidogrel and PPIs (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.