In this large multi-center randomized controlled trial, over 2500 patients with acute stroke were randomized to thigh -high graduated compression stockings (GCS) or usual care. There was no significant difference in the risk of DVT (10% in GCS and 10.5% in usual care), but skin issues (breaks, ulcers, blisters, and necrosis) was much more common in the GCS group (5%) compared to usual care (1%). This study does not support the use of GCS in acute stroke patients, as there is no evidence of benefit, and some evidence of harm (abstract).
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