In this before-after observational cohort of surgical ICU patients with suspected infection, those that received aggressive antibiotics (started with suspected infection after cultures were sent) had significantly higher adjusted mortality (odds ratio 2.5, CI 1.5 to 4.0) compared to those that received conservative antibiotics (started only after objective confirmation of infection) . The conservative antibiotic group also had a shorter mean duration of therapy, and higher initial appropriate therapy. Conserving antibiotics for only patients with confirmed infection may improve outcomes in surgical ICU patients (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.