Downside of oral/digestive decontamination

In a randomized controlled trial published in 2009 (abstract), intubated ICU patients who underwent oral/digestive decontamination had lower mortality than control patients. However, a follow-up study from this trial shows that the the point prevalence of resistant gram-negative colonization rates were higher after the intervention than before the intervention. This may give pause to those ICU’s considering routine decontamination protocols, and further long-term follow-up of clinical outcomes from this study will be interesting (abstract).

Danielle Scheurer

Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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