In this trial of 161 pediatric patients in an ED with skin/soft tissue infections (of which 80% were CA-MRSA), after incision and drainage, they were randomized to 10 days of placebo or antibiotics (trimethoprim-sulfamethoxazole). Ten day treatment failure was similar between the groups (5% and 4%) as was 30 day lesion recurrence (29% and 28%). There does not appear to be an advantage to antibiotics after incision and drainage of MRSA skin and soft tissue infections (abstract).
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.