In this trial of patients with left-sided endocarditis, large vegetations, and severe valve disease, they were randomized to early surgical intervention, or conventional (antibiotic) therapy. The surgical group had significantly lower risk of the combined outcome (death, embolic event, recurrent) at 6months, compared to the conventional group (3% vs 28%, hazard ration 0.08, 95% CI 0.01 to 0.65, p=0.02). Early surgical referral should be made for patients with left sided infective endocarditis with large vegetations and valve disease (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.