In this trial of 3002 patients with acute symptomatic superficial vein thrombosis (without DVT/PE), they were randomized to fondaparinux 2.5mg a day or placebo for 45 days. The intervention group had significantly fewer events (death, PE/DVT, or recurrence) than the placebo group (1% vs 6%) with major bleeding about 1% in each group. Fondaparinux should be considered for patients with acute symptomatic superficial venous thrombosis (abstract)
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