The FDA has issued a warning on the risk of hypomagnesemia with long term PPI use. The proposed mechanism is reduced Mg absorption after long term use. The clinical significance and incidence is not yet known, but some patients in the report did not respond to Mg supplementation and had to be discontinued off their PPI (FDA site)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]