IV PPI’s for bleeding ulcers

In this multi-center RCT, over 700 patients with EGD-proven bleeding peptic ulcers were randomized (after endoscopy) to 72 hours of IV PPI (80mg bolus, then 8mg/hr) or placebo. Those in the PPI group had less recurrent bleeding at 72 hours (6% vs 10%) and less endoscopic re-treatment (6% vs 12%), surgery (3% vs 5%), and death (1% vs 2%). Of note, this only applies to post-endoscopy bleeding peptic ulcers, and does not address either oral PPI therapy, or pre-endoscopy PPI therapy (abstract).

Danielle Scheurer

Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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