In this large randomized trial of high risk hospitalized patients (eg >age 40 with CHF, cancer, or infection with at least 1 other risk factor for VTE), all cause mortality and major bleeding were no different between those receiving LMWH (40 qday) versus graduated compression stockings. Although this study was not designed to evaluate rate of asymptomatic or symptomatic VTE, there was only 1 fatal PE in each group. The caveats are that this international population had lower risk of VTE than past US study populations (lower rate of a past history of VTE, lower BMI), but nonetheless, mortality and bleeding did not differ between LMWH and stockings in these population of hospitalized medical patients (abstract)
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