In this prospective validation of 676 patients presenting with an UGI bleed (hematemesis, coffee grounds, or melena), of the patients with a score of 0 on the Glasgow-Blatchford bleeding score (16%), none of them required an intervention (EGD, transfusion, or surgery) and none of them died. Unlike other scores, it is based only on clinical (not EGD) parameters. A score of 0 includes: BUN<18, Hb>13 (men) or >12 (women), SBP >110, pulse <100, and no history of melena, syncope, CHF, or liver disease. Those with a score of 0 likely do not need hospitalization or urgent EGD, and can be managed as an outpatient (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]