In this large derivation and validation cohort, 5 clinical risk factors were found to significantly increase the risk of death in those presenting with acute UGI bleed: these included age >65, altered mental status, systolic BP<90, INR >1.5, or albumin <3. The risk of death increased with the number of factors present, from <1% to 25% with zero to 5 factors, respectively. This can be used to predict need for urgent endoscopy and/or ICU disposition (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]