In trial of 173 enrolled patients with acute liver failure (not attributed to acetaminophen), they were randomized to placebo or IV N-acetylcysteine (NAC). Although overall survival at 3 weeks was similar between the groups, transplant free survival was significantly higher at 1 year in the NAC group (40% vs 27%), although the benefit was found only in patients with mild encephalopathy (abstract). NAC is beneficial in patients with early stage, non-acetaminophen liver failure.
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]