In this meta-analysis of 7 high-quality randomized trials evaluating the comparative efficacy of high-dose (80mg IV followed by 8mg infusion) versus non-high-dose PPIs, researchers found no difference in re-bleeding, mortality, or surgical intervention between the 2 groups. High dose PPI’s do not appear to be justified in patients post EGD in bleeding peptic ulcers (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.