In this meta-analysis of 7 high-quality randomized trials evaluating the comparative efficacy of high-dose (80mg IV followed by 8mg infusion) versus non-high-dose PPIs, researchers found no difference in re-bleeding, mortality, or surgical intervention between the 2 groups. High dose PPI’s do not appear to be justified in patients post EGD in bleeding peptic ulcers (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]