In this large nationwide analysis from Denmark, the use of any NSAID after an MI was associated with a significant risk of recurrent MI or death (hazard ratio 1.5; 95% CI, 1.3to 1.6). The risk persisted despite NSAID type, but was highest for diclofenac and lowest for naproxen. The AHA advisory statement from 2007 recommends avoiding NSAIDs after an MI, but using naproxen if absolutely necessary, which is consistent with the findings here (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.