In this large administrative database analysis, the use of recombinant Factor VIIa use in US hospitals from 2000 to 2008 increased by 140 fold, 97% of which were off-label in 2008. It was most commonly utilized for CV surgery, ICH, and trauma patients. All cause mortality among patients receiving it was 27% (abstract). In addition, a systematic review found that the use of FactorVII in a variety of conditions did not improve mortality, and did increase arterial thromboses (abstract). Hospitals should evaluate their use of rFactorVII to determine costs, risks, and benefits
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April 18, 2011 |
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About the Author: Danielle Scheurer
Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.
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