This systematic review compared the efficacy and safety of the oral Xa inhibitors vs enoxaparin in patients post hip or knee arthroplasty; the Xa agents slightly reduced the risk of symptomatic DVT (by 3 events for every 1000 patients treated) compared to enoxaparin, at the risk of an increase in major bleeding events (by 2 events for every 1000 patients treated) for all doses, but no increased risk for low doses. Low dose Xa inhibitors may be as safe and more effective than enoxaparin for VTE prophylaxis post hip and knee arthroplasty (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.