In this diagnostic trial of 121 samples of pleural fluid from patients with a pleural effusions and known / suspected malignancy, the sensitivity for detecting malignancy was higher with larger pleural fluid volumes. The sensitivity using direct smear/cytospin for the 10cc, 60cc, or >150cc submissions were 49%, 63%, and 69%. Adding cell blocks increased the sensitivity to 76%, 80%, and 87%. Larger pleural fluid volumes increase cytology sensitivity in patients with suspected malignancy (abstract).
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.