In this retrospective analysis of a large database, researchers found that patients recently discharged after an MI or stent on PPI-clopidogrel had a 93% higher risk of re-hospitalization for MI (and 64% higher risk for re-hospitalization for MI or stent) than patients on clopidogrel without a PPI. This association was found despite type of PPI (omeprazole or pantoprazole). The current warning on PPI labeling, to avoid concomitant use with clopidogreal when able, is probably warranted, until the controversy can be resolved (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.