There is mounting evidence that PPI use is associated with higher risk for a number of infectious diseases (including clostridium difficile, SBP, and pneumonia). In this large prospective cohort, researchers examined the strength of association between PPIs and hospital acquired pneumonia (HAP), and found a 30% higher risk of HAP in those on PPIs than those not on PPIs (after multivariable adjustment). They did not find a significant association with H2 blockers (abstract). Over half of the inpatients received an acid suppressive medication during their inpatient stay. This study adds to the existing literature of the overuse and potential harm of acid suppressive medications in inpatients.
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May 27, 2009 |
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About the Author: Danielle Scheurer
Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.
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