In this case control study of cirrhotics with ascites, those on PPIs had a much higher risk of SBP than those not on PPIs (adjusted OR 4.3), and about half of the patients on PPIs had no indication. Although this study can not establish causality, it reminds us to review the necessity of PPIs in all inpatients, given the mounting evidence of potential harm of PPIs (risk of pneumonia, Clostridium difficile, fractures, and lower clopidogrel efficacy) (abstract).
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]