PPIs increase risk of SBP in hospitalized cirrhotics

In this case-control study from a single institution of patients hospitalized with cirrhosis, those that developed SBP were almost twice as likely to have received a PPI in the previous 7 days (71% versus 42%), and those who had not taken a PPI in the past 90 days had a 70% lower odds of developing SBP compared to those that had received a PPI within the last 7 days. Although retrospective, this study should cause us to pause and consider the risks of starting or maintaining PPI therapy in patients hospitalized with cirrhosis (abstract)

Danielle Scheurer

Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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