In this large retrospective cohort, researchers determined a risk prediction score for Cdiff that had good predictive discrimination (C index 0.88); many of the risk factors are already well known, and include: age, Cdiff “density”, previous 60 day admits, modified Acute Physiology Score, high-risk antibiotic days, low albumin, ICU admission, and receipt of laxatives, gastric acid suppressors, or antimotility drugs. If further validated, this risk score may be used clinically to predict risk, and determine which patients need additional preventive strategies layered on (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]