In this prospective multi-center trial of 630 ICU patients, patients were randomized to pro-calcitonin guided antibiotics or usual care. The pro-calcitonin group had antibiotics started or stopped based on pre-determined pro-calcitonin levels. There was no difference in 28 or 60 day mortality between the groups, but days of antibiotics were less in the pro-calcitonin group (12 vs 14 days). Although this study did not show any difference in outcomes measures, antibiotic use can be reduced by the use of pro-calcitonin guided therapy (abstract).
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.