In this prospective multi-center trial of 630 ICU patients, patients were randomized to pro-calcitonin guided antibiotics or usual care. The pro-calcitonin group had antibiotics started or stopped based on pre-determined pro-calcitonin levels. There was no difference in 28 or 60 day mortality between the groups, but days of antibiotics were less in the pro-calcitonin group (12 vs 14 days). Although this study did not show any difference in outcomes measures, antibiotic use can be reduced by the use of pro-calcitonin guided therapy (abstract).
by Deepak Asudani, MD, MPH, FHM Whether it is the prompt and expeditious international collaboration to develop an Ebola vaccine, or tardy but promising development of the first anti parasitic malarial vaccine or the fascinating technology utilizing synthetic DNA for vaccine development against MERS, these developments promise to highlight significant strides in vaccine development for […]
Economists describe preferences in two ways: revealed and stated. Say, for example, I asked you to implement a penalty program for your team with the goal of decreasing the number of occasions members did not clean their hands after a patient encounter. Because you know bad hands equal bad outcomes, you’re apt to offer up […]
by Eric Howell, MD, SFHM “Tell me what you know about antibiotics.” That’s the discussion I start with hospitalized patients all the time, right after they ask me to prescribe antibiotics for their simple cough, or other viral-like illness. And, from their perspective, asking for antibiotics makes sense. After all, antibiotics have been the physician’s […]