In this prospective observational cohort of patients with infective endocarditis treated with gentamycin, researchers quantified the change in creatinine clearance with duration of therapy. They found the mean decrease in creatinine clearance in gentamycin treated patients was 9% (median duration 14 days) at a rate of 0.5% decrease per day. This is useful to know the expected reduction in creatinine clearance, although fortunately there was no correlation with the creatinine clearance reduction and mortality (abstract)
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