Quantifying nephrotoxicity of gentamycin in endocarditis

In this prospective observational cohort of patients with infective endocarditis treated with gentamycin, researchers quantified the change in creatinine clearance with duration of therapy. They found the mean decrease in creatinine clearance in gentamycin treated patients was 9% (median duration 14 days) at a rate of 0.5% decrease per day. This is useful to know the expected reduction in creatinine clearance, although fortunately there was no correlation with the creatinine clearance reduction and mortality (abstract)

Danielle Scheurer

Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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