In this single center prospective cohort, patients undergoing cardiothoracicsurgery were all givennasal mupirocin decolonization (for 5 days preop), and prophylactic pre-operative vancomycin (if they were MRSA nasal carriers), and mupirocin to all chest tube sites after withdrawal. The rate of MRSA wound infections decreased 93% from before to after the intervention (with no institutional change in the rate of MRSA infections among non-cardiothoracic patients). This 3 tiered MRSA eradication intervention in cardiothoracic surgery patients can reduce the risk of MRSA post op infections (abstract)
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