This large single center cohort found several factors associated with the risk of non-ICU GI bleeding; researchers developed a scoring system to determine which patients were at highest risk of bleeding (and presumably would benefit from GI prophylaxis). The following factors were included (including their score): age >60 (2), male (2), acute renal failure, (2) liver disease (2), sepsis (2), VTE prophylaxis (2), coagulopathy (3), medical service (3). Those at highest risk (score 12+) had a GI bleed in 3.2% of those not on GI prophylaxis, and 1.1% of those on GI prophylaxis. This helps define those non-ICU hospitalized patients that would benefit from GI prophylaxis (abstract).
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]