In this large meta-analysis of 61 randomized controlled trials, low dose ASA increased the risk of major GI bleeding by over 55% (OR 1.55, CI 1.27-1.90); but compared to low dose ASA, clopidogrel and anticoagulants almost doubled the odds of major GI bleeding (OR 1.86 and 1.93, respectively). The addition of a PPI to low dose ASA reduced the risk of major GI bleeding by 2/3 (OR 0.34, CI 0.21-0.57). This meta-analysis helps quantify the risks of GI bleeding with these 3 agents (abstract)
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November 18, 2011 |
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About the Author: Danielle Scheurer
Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.
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