Risk of nosocomial Cdiff and PPI use

In this large retrospective database analysis, increasing acid suppressive intensity (from none to H2 blockers, to daily PPIs, to more than daily PPIs) linearly increased the risk of nosocomial Cdiff infection (from 0.3%, 0.6%, 0.9%, and 1.4% respectively), with corresponding adjusted odds ratios of 1, 1.5, 1.7, and 2.4 respectively. Intensity of acid suppressive therapy linearly increases the risk of nosocomial Cdiff infection (abstract)

Danielle Scheurer

Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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