In this large retrospective database analysis, increasing acid suppressive intensity (from none to H2 blockers, to daily PPIs, to more than daily PPIs) linearly increased the risk of nosocomial Cdiff infection (from 0.3%, 0.6%, 0.9%, and 1.4% respectively), with corresponding adjusted odds ratios of 1, 1.5, 1.7, and 2.4 respectively. Intensity of acid suppressive therapy linearly increases the risk of nosocomial Cdiff infection (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]