Sodium polystyrene sulfonate (SPS or Kayexalate), a treatment for hyperkalemia, was approved by the FDA in 1958, which was before the time the FDA required safety and efficacy reporting for drug approval. In 2009, the FDA issued a warning about the association of kayexalate-sorbitol use (which is the common preparation used in the US) due to reports of colonic necrosis. This study reviewed efficacy data for kayexalate-sorbitol and found no convincing evidence that it significantly lowers serum potassium. Given the lack of efficacy data, and recent reports of harm, we should question our use of this drug in hospitalized patients (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]