Selective outcome reporting in clinical trials

Researchers analyzed all randomized controlled trials listed in pubmed in 2008 in 3 clinical area (GI, cardiology, and rheumatology) in 10 high impact clinical journals. They found that of the 323 trials, only 46% were adequately registered (registered before the end of the trial with the primary outcome cleared stated). Among those adequately registered, 31% had a discrepancy in the registered primary outcome and the published primary outcome (including omission of the primary outcome, reporting a secondary outcome as primary, and reporting unregistered outcomes as primary). Despite registration requirements for most high impact journals, many trials are not publishing the intended primary outcomes measures (abstract)

Danielle Scheurer

Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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