In this cohort of HIV patients with PCP, a serum B-glucan level >23 pg/mL (the threshold of detection for that assay) had a sensitivity and specificity of 96% and 88% respectively (over half of these patients also had candidiasis). Of note, the level did not correlate with severity of hypoxia, serum LDH, or response to treatment. Serum B-glucan is a sensitive and specific diagnostic test for PCP in HIV patients (abstract).
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.