This meta-analysis found vasopressin receptor antagonists are effective at raising serum sodium levels in patients with euvolemic and hypervolemic hyponatremia. Normalization of serum sodium occurred significantly earlier with these agents than without, and were more effective in euvolemic than hypervolemic patients. There was also no increase risk of adverse events or hypernatremia, and no reported demyelination syndromes. Although these agents seem to be still finding their role in clinical medicine, they do appear to be safe and moderately effective based on this meta-analysis (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.