In this randomized trial of ICU patients, they were given Dalteparin (5000 IU SQ qday) or unfractionated heparin (5000 IU SQ BID); there was no difference in rates of proximal DVT, major bleeding, or death, but rates of PE were significantly lower with dalteparin (1.3% vs 2.3%), as were rates of HIT (hazard ratio 0.27, CI 0.08 to 0.98). Dalteparin is equivalent to UFH in rates of DVT, but has lower risk of PE and HIT (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.