In thislarge multicenter RCT of over 1500 cancer patients receiving chemotherapy through central venous catheters, they were randomized to fixed dose warfarin (1mg/day), dose adjusted warfarin(INR 1.5-2), or no warfarin. There was no difference in the groups in either catheter or non-catheter thrombosis. There is no role in cancer patients for warfarin in central venous catheter thrombosis prevention (abstract).
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