Another oral Factor Xa inhibitor

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By  |  August 12, 2009 | 

Oral factor Xa inhibitors are attractive options for preventing post-op thromboembolic disease, since they are given at a fixed dose and do not require serum monitoring. In this randomized trial, 3195 post-op total knee replacement patients were randomized to apixaban (2.5mg po BID) or enoxaparin (30mg SQ BID) for 10-14 days. The primary outcome (DVT, PE, or death) occurred in 9% in each group, with less bleeding in the apixaban group (3% vs 4%). Apixaban is a promising new oral agent for post-op thromboembolism prevention, pending FDA approval (abstract).

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About the Author: Danielle Scheurer

Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.

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