The Association for Professionals in Infection Control (APIC) has released a comprehensive prevalence survey on the state of Cdiff in US healthcare facilities (from 648 facilities in 47 states) (link). They found 13 / 1000 inpatients were infected or colonized with Cdiff (94% infected). Over half (54%) were detected in <48 hours of admission (indicating infection at the time of admission), 20% had no history of antibiotic exposure (and 17% only exposed to surgical prophylactic antibiotics), and over half (53%) still had diarrhea after 6 days of treatment. This prevalence survey reminds us to be vigilant for Cdiff in all inpatients with diarrhea (with or without a history of antibiotic use), and to be patient with its treatment course (over half still with symptoms at 6 days).
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How much of this is related to indiscriminate use of Antibiotics? How much of this is related to unfounded use of PPI for GI prophylaxis in non critical patients?