This prospective cohort of 2781 patients describes the contemporary (2000-2005) presentation, etiology, and outcomes of infective endocarditis. The disease affected native valves 72% of the time, most commonly mitral (41%) followed by aortic (38%), and the most common organism was staph aureas (31%). Complication rates were high, including CHF (32%), stroke (17%), other emboli (23%), and abcess (14%). In hospital death was 18%, and higher risk for death included older age, staph organism, prosthetic valve, mitral location, and the presence of CHF. Risk of death was lower for strep viridans. (abstract)
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