In this industry sponsored randomized trial of 1952 healthy adults (aged 18 to 49), the inactivated (intramuscular) vaccine outperformed the live-attenuated (nasal spray). Overall 6% of participants had lab-confirmed influenza, and there was a 50% reduction in influenza cases in the inactivated vaccine group compared to the live-attenuated group. Inactivated seasonal influenza vaccination reduces lab-confirmed influenza more than live-attenuated in healthy adults (abstract).
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