In this multi-center RCT, over 700 patients with EGD-proven bleeding peptic ulcers were randomized (after endoscopy) to 72 hours of IV PPI (80mg bolus, then 8mg/hr) or placebo. Those in the PPI group had less recurrent bleeding at 72 hours (6% vs 10%) and less endoscopic re-treatment (6% vs 12%), surgery (3% vs 5%), and death (1% vs 2%). Of note, this only applies to post-endoscopy bleeding peptic ulcers, and does not address either oral PPI therapy, or pre-endoscopy PPI therapy (abstract).
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]