In this multi-center RCT, over 700 patients with EGD-proven bleeding peptic ulcers were randomized (after endoscopy) to 72 hours of IV PPI (80mg bolus, then 8mg/hr) or placebo. Those in the PPI group had less recurrent bleeding at 72 hours (6% vs 10%) and less endoscopic re-treatment (6% vs 12%), surgery (3% vs 5%), and death (1% vs 2%). Of note, this only applies to post-endoscopy bleeding peptic ulcers, and does not address either oral PPI therapy, or pre-endoscopy PPI therapy (abstract).
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May 4, 2009 |
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About the Author: Danielle Scheurer
Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.
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