Labs for diagnosing Wilson’s disease

By  |  December 17, 2008 | 

In this case control study from the Acute Liver Failure Study Group registry, researchers determined that the combination of 3 simple lab tests diagnosed Wilson’s disease as a cause of acute liver failure with a sensitivity and specificity of 100%. These included AST:ALT ratio >2.2, alkaline phosphatase:total bilirubin ratio <4, and ceruloplasmin <20 mg/dL. Although this combination needs to be validated prospectively, this is an easy way to narrow the differential in patients presenting with acute liver failure (abstract)

Leave A Comment

About the Author:

Danielle Scheurer
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

Categories

Related Posts

By  | June 29, 2013 |  0
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
By  | June 22, 2013 |  0
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
By  | May 25, 2013 |  0
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]