In this large retrospective propensity-matched cohort of patients hospitalized in a non-ICU setting for a LOS of at least 3 days, the risk of GI bleeding was significantly, but modestly, lower in those that received GI prophylaxis (adjusted odds ratio 0.63, CI 0.42 to 0.93). However, the number needed to treat to prevent 1 bleed was 770 (based on a prevalence of GI bleeding of 0.3%). Routine use of GI prophylaxis in non-critically ill patients should continue to be discouraged (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]