In this large retrospective propensity-matched cohort of patients hospitalized in a non-ICU setting for a LOS of at least 3 days, the risk of GI bleeding was significantly, but modestly, lower in those that received GI prophylaxis (adjusted odds ratio 0.63, CI 0.42 to 0.93). However, the number needed to treat to prevent 1 bleed was 770 (based on a prevalence of GI bleeding of 0.3%). Routine use of GI prophylaxis in non-critically ill patients should continue to be discouraged (abstract)
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